Boyue Zhang
Boyue Zhang
Undergraduate in Biological SciencesComputational Biology · Protein Engineering
College of Life Sciences, Zhejiang University
To design is to converse with what evolution has already written.

About

I am an undergraduate in Biological Sciences at Zhejiang University, working on computational protein design and multi-omics analysis. I am currently a research intern at the Walter and Eliza Hall Institute through the InSPIRE program, where I work on CAR-T receptor design.

At WEHI I am supervised by Dr. Emma Petley in the labs of Prof. Matt Call and A/Prof. Melissa Call, testing whether a costimulatory receptor rebuilt into its native trimeric form makes T cells activate better.

At Zhejiang University I work with Dr. Yangwei Jiang in Prof. Ruhong Zhou’s lab on enzyme design — we redesigned the rate-limiting enzyme of astaxanthin biosynthesis and confirmed the prediction at the bench — and with Dr. Wenbin Zhou in Prof. Meihua Sui’s lab on the multi-omics basis of sex-biased liver cancer. I was Technical Lead of ZJU-China’s iGEM 2025 team, LumaManta.

What draws me is the point where a computational prediction has to survive contact with an experiment: protein and enzyme design, molecular dynamics, and the omics side of disease biology. This autumn I will spend a semester at the Chinese University of Hong Kong on the IASP exchange.

Sep 2026 — Dec 2026
Exchange Student, International Asian Studies Programme (IASP)
Jun 2026 — Present
Internship Student, InSPIRE Program
Sep 2023 — Jun 2027 (Expected)
B.S. in Biological Sciences

Projects

Supervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa Call
WEHI Call Lab 2026 Ongoing
Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.
Advised by Dr. Yangwei Jiang & Prof. Ruhong Zhou
ZJU Zhou Lab 2025 Ongoing
Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.
LumaManta — Programmable Biosensing for Water Monitoring
Technical Lead, ZJU-China · Advised by Prof. Ming Chen & Prof. Fan Yang
iGEM 2025 Chen Lab 2025 Silver Medal
Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.
Sex Dimorphism in DEN/TCPOBOP-Induced Hepatocellular Carcinoma
Advised by Dr. Wenbin Zhou & Prof. Meihua Sui
ZJU Medicine Sui Lab 2026 Ongoing
Tracing sex-biased metabolites across 174 mice from hepatitis through cirrhosis to HCC, then reversing them with estrogen supplementation.
A Sustainable Pigment Biosynthesis System
Advised by Prof. Ming Chen
ZJU Chen Lab 2025 Outstanding
Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.

2026

Supervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa Call
WEHI Call Lab 2026 Ongoing
Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.
Sex Dimorphism in DEN/TCPOBOP-Induced Hepatocellular Carcinoma
Advised by Dr. Wenbin Zhou & Prof. Meihua Sui
ZJU Medicine Sui Lab 2026 Ongoing
Tracing sex-biased metabolites across 174 mice from hepatitis through cirrhosis to HCC, then reversing them with estrogen supplementation.

2025

Advised by Dr. Yangwei Jiang & Prof. Ruhong Zhou
ZJU Zhou Lab 2025 Ongoing
Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.
LumaManta — Programmable Biosensing for Water Monitoring
Technical Lead, ZJU-China · Advised by Prof. Ming Chen & Prof. Fan Yang
iGEM 2025 Chen Lab 2025 Silver Medal
Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.
A Sustainable Pigment Biosynthesis System
Advised by Prof. Ming Chen
ZJU Chen Lab 2025 Outstanding
Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.

bioinformatics

Sex Dimorphism in DEN/TCPOBOP-Induced Hepatocellular Carcinoma
Advised by Dr. Wenbin Zhou & Prof. Meihua Sui
ZJU Medicine Sui Lab 2026 Ongoing
Tracing sex-biased metabolites across 174 mice from hepatitis through cirrhosis to HCC, then reversing them with estrogen supplementation.

cancer biology

Sex Dimorphism in DEN/TCPOBOP-Induced Hepatocellular Carcinoma
Advised by Dr. Wenbin Zhou & Prof. Meihua Sui
ZJU Medicine Sui Lab 2026 Ongoing
Tracing sex-biased metabolites across 174 mice from hepatitis through cirrhosis to HCC, then reversing them with estrogen supplementation.

enzyme engineering

Advised by Dr. Yangwei Jiang & Prof. Ruhong Zhou
ZJU Zhou Lab 2025 Ongoing
Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.

igem

LumaManta — Programmable Biosensing for Water Monitoring
Technical Lead, ZJU-China · Advised by Prof. Ming Chen & Prof. Fan Yang
iGEM 2025 Chen Lab 2025 Silver Medal
Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.

metabolic engineering

A Sustainable Pigment Biosynthesis System
Advised by Prof. Ming Chen
ZJU Chen Lab 2025 Outstanding
Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.

molecular dynamics

Supervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa Call
WEHI Call Lab 2026 Ongoing
Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.
Advised by Dr. Yangwei Jiang & Prof. Ruhong Zhou
ZJU Zhou Lab 2025 Ongoing
Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.

multi-omics

Sex Dimorphism in DEN/TCPOBOP-Induced Hepatocellular Carcinoma
Advised by Dr. Wenbin Zhou & Prof. Meihua Sui
ZJU Medicine Sui Lab 2026 Ongoing
Tracing sex-biased metabolites across 174 mice from hepatitis through cirrhosis to HCC, then reversing them with estrogen supplementation.

optogenetics

LumaManta — Programmable Biosensing for Water Monitoring
Technical Lead, ZJU-China · Advised by Prof. Ming Chen & Prof. Fan Yang
iGEM 2025 Chen Lab 2025 Silver Medal
Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.

protein design

Advised by Dr. Yangwei Jiang & Prof. Ruhong Zhou
ZJU Zhou Lab 2025 Ongoing
Combining Rosetta FuncLib with protein language models to redesign the rate-limiting astaxanthin ketolase, validated in vitro at +46.7% yield.

protein engineering

Supervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa Call
WEHI Call Lab 2026 Ongoing
Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.

srtp

A Sustainable Pigment Biosynthesis System
Advised by Prof. Ming Chen
ZJU Chen Lab 2025 Outstanding
Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.

structural biology

Supervised by Dr. Emma Petley · PIs: Prof. Matt Call & A/Prof. Melissa Call
WEHI Call Lab 2026 Ongoing
Redesigning a CAR-T costimulatory transmembrane domain back into its native trimeric form, screened by 2 µs MD and validated by flow cytometry and degranulation assays.

synthetic biology

LumaManta — Programmable Biosensing for Water Monitoring
Technical Lead, ZJU-China · Advised by Prof. Ming Chen & Prof. Fan Yang
iGEM 2025 Chen Lab 2025 Silver Medal
Converting two light inputs into four sensor proteins on demand with CRISPR logic gates, packaged as an all-in-one device for water pollutant and eDNA monitoring.
A Sustainable Pigment Biosynthesis System
Advised by Prof. Ming Chen
ZJU Chen Lab 2025 Outstanding
Engineering vioE activity and pathway flux for pigment yield, with light- and quorum-controlled circuits that make the output switchable.

All projects →

Selected Honors

WEHI InSPIRE Scholarship 8,000 AUD; competitively selected, ZJU-nominated
Silver Medal, iGEM 2025 Technical Lead — ZJU-China, LumaManta
Grand Prize, SynBio Challenges 1st place nationally
Gold Medal, 18th "Dandelion" Undergraduate Innovation Competition CTO — LumaManta eDNA-based aquatic pathogen detection
First Prize (Champion), 2nd "Forbel Cup" National Pet Industry Innovation Competition Led the “Pet Smart Health” team
Provincial SRTP Research Grant — rated Outstanding 12,000 RMB
5th Place, Stand-Up Paddleboard 200 m
Academic Honors & Scholarships
  • Professional Excellence Scholarship (2023–2024)
  • Second-Class Scholarship (2024–2025)
  • Innovation & Entrepreneurship Model (2024–2025)
  • Academic Excellence Model (2024–2025)

Invited Talks

Invited Speaker, 2025 iGEM Jamboree Presented LumaManta’s biosensing design to the international iGEM community.